SLC1A2 and infantile epilepsy syndrome: Petr et al. (2015) reported that only astrocytic but not neuronal deletion of GLT1 induced seizure activity, suggesting that the function of an astrocytic membrane protein is particularly important in the pathophysiology of multiple behaviors related to glutamatergic system. Furthermore, brain-region-specific deletion of GLT1 in the diencephalon, brainstem, and spinal cord could result in excess mortality and lethal spontaneous seizure (Sugimoto et al., 2018). Likewise, GLT1 dysfunction in the dorsal forebrain is involved in the pathogenesis of infantile epilepsy (Sugimoto et al., 2018).