ASCL1 and Parkinson disease: In contrast, in a mouse PD model that was induced by 6-hydroxydopamine (6-OHDA), striatal astrocytes were reported to be directly converted into dopaminergic neurons when a cocktail of four transcription factors (Neurod1, Ascl1, Lmx1a, and miR218) was delivered into the ipsilateral striatum (Rivetti di Val Cervo et al., 2017).