To determine the role of VMEC monolayers on tumor cell TEM in spines loaded with CX3CL1, we used fluorescently labeled lung cancer cells (A-549) and renal cancer cells (786-O) to assess changes in the TEM rate of cancer cells after regulating the activity of Src/P115-RhoGEF/ROCK signaling in VMECs. This evidence concerns the gene SRC and renal carcinoma.