AQP4 and epilepsy: In recent years, studies have shown an association between the glial water channel aquaporin-4 (AQP4) and Kir 4.1, forming an astrocytic protein complex responsible for removing potassium from the extracellular space, being an important mechanism in establishing a hyperpolarized neuronal membrane potential which may play an important role in epilepsy (Aronica et al., 2000; Das et al., 2012; Devinsky et al., 2013).