AQP4 and epilepsy: Furthermore, AQP4 knockout animals are also more susceptible to seizures and epilepsy (Dudek and Rogawski, 2005; Devinsky et al., 2013) and, in kainate-induced epileptic animal models, a reduction in AQP4 expression was also reported (Lee et al., 2012; Devinsky et al., 2013).