AR and posterior cortical atrophy: This systematic review and meta-analysis demonstrated that the AR-V7-positive proportion is frequently up-regulated in CRPC as compared to newly diagnosed PCa (OR 7.06 95% CI 2.52–19.83, P < 0.001), and may emerge as an adaptive response to therapies targeting the AR-signaling axis, which is consistent with previous reports [5, 6, 13].