Tumour-infiltrating microglia and macrophages display the pro-tumorigenic, immunosuppressive phenotype in gliomas.1 We studied the expression of genes recognised as markers of pro-tumorigenic (IL10, MYC) and inflammatory (IRF7, IL1B) phenotypes in primary human microglia cultures treated with LN18 and U87 glioma conditioned medium (GCM). Here, IRF7 is linked to central nervous system cancer.