In the context of leukaemia, it is known that MLL3 functions as a tumour suppressor in 7q acute myeloid leukaemia (AML), and short hairpin RNA (shRNA) knockdown or CRISPR-Cas9-mediated deletion of Mll3 generates a transplantable and fatal leukaemia in p53-null HSPCs [102]. Here, TP53 is linked to leukemia.