Treatment with antioxidant vitamins (vitamins C and E), SOD mimetics (tempol [4-hydroxy-2,2,6,6-tetramethyl piperidinoxyl]), free radical scavengers (N-acetyl-l-cysteine), tetrahydrobiopterin, nonspecific Nox inhibitors (apocynin, diphenylene iodinium), and specific Nox inhibitors (gp91dstat, GKT compounds) reduce oxidative stress and ameliorate or prevent development of hypertension and associated target-organ damage.58, 59, 60, 61. Here, SOD1 is linked to hypertensive disorder.