NLRP3 and hypertensive disorder: As part of the innate immune system, inflammasomes seem to be especially important in inflammation, with increasing evidence suggesting a role for ROS-induced regulation of inflammasomes in hypertension149,150 The NLRP3 inflammasome platform may play a key role in coordinating inflammatory responses in hypertension, especially in the context of caspase-1–, IL-1β–, and IL-18–mediated reactions.