AGT and pulmonary arterial hypertension: Oxidative stress has been causally linked to increased blood pressure in various experimental models of hypertension, including genetic hypertension (spontaneously hypertensive rats [SHRs], stroke-prone SHRs [SHR-SPs]), endocrine-induced hypertension [Ang II, aldosterone, deoxycorticosterone acetate (DOCA)]), surgically induced hypertension (2-kidney 1-clip [2K1C], aortic banding), diet-induced hypertension (salt, fat, zinc), neurogenic hypertension, pulmonary hypertension, and preeclampsia.17