EGLN1 and obesity due to melanocortin 4 receptor deficiency: Another group shows that transgenic mice with adipose tissue-specific knockout of Phd2 (for constitutive expression of Hif) are resistant to high-fat diet-induced obesity with fewer lipid droplets in white adipose tissue and increased Ucp1 expression in brown adipose tissue [97], while adipocyte-specific knockout of Phd2 induces adiposity in mice under chow diet (low-fat) [102].