Hypoxia/HIF signaling directly facilitates the EMT gene profile to induce the invasiveness of cancer cells [117] through recognition of HREs of EMT transcription factors zinc finger E-box-binding homeobox 1 (ZEB1), snail family transcriptional repressor 1 (SNAI1), and twist family bHLH transcription factor 1 (TWIST1) genes [154]. Here, TWIST1 is linked to cancer.