VEGF-D binds to the tyrosine kinase receptors (TKRs) VEGFR-2 and VEGFR-3 that are expressed specifically on the surface of GC cells, which then activates the downstream signaling pathways, including the phosphatidylinositol 3 kinase (PI3K)/AKT, protein kinase C (PKC), and mitogen-activated protein kinase (MAPK) pathways [21], to induce angiogenesis within the solid tumors, promoting tumor growth and distant metastasis [17, 34]. This evidence concerns the gene VEGFD and neoplasm.