Existing studies have shown that SOX5, SOX9 and SOX6 could be used as a drug target for INSULIN and DEXAMETHASONE, for the treatment of neurological diseases [38, 39], indicating that the combination of drugs and genes can reach the blood-brain barrier, so whether they could also be used as a drug target for solid tumor GBM, needs further research and mining by our research group. This evidence concerns the gene SOX5 and glioblastoma.