DGKE and nephrotic syndrome: In 2013 recessive mutations in DGKE, which encodes diacylglycerol kinase epsilon (DGKE), were first reported to cause atypical hemolytic uremic syndrome (aHUS)1 and nephrotic syndrome, with glomerular microangiopathy said to resemble membranoproliferative (mesangiocapillary) glomerulonephritis (MPGN)2 (Online Mendelian Inheritance in Man #615008), though the pathophysiological mechanisms remain poorly understood.