CASR and hypercalcemia disease: In 41,489 individuals not treated with cinacalcet or vitamin D, we identified 333 individuals (0.78%) with overt hypercalcemia (≥10.2 mg/dL, range 10.2 to 12.8 mg/dL); the 25 individuals with rare LoF or mLoF CASR variants having mean serum Ca concentrations ≥ 10.2 mg/dL represented 7.5% of overtly hypercalcemic individuals.