PLEK and myelofibrosis: Additional genes not previously implicated as regulators of megakaryocyte versus erythroid differentiation showed striking differential expression between the erythroid and megakaryocyte trajectories, including YBX1, HMGA1, PLEK, SOX4, and MYC (Figures 4B and 4C), suggesting additional targets for strategies to specifically inhibit pathological megakaryopoiesis while preserving erythropoiesis in myelofibrosis patients.