USF2 and epilepsy: With regard to the top novel epilepsy-associated predictions, CACNA1B is associated with the voltage-gated calcium channel that has been only recently implicated in epileptic phenotypes.35, 36, 37USF1 deficiency in mice (in combination with USF2 knockout) has been shown to cause epileptic seizures,38 suggesting the important role this gene plays in normal brain function.