NOS2 and chronic kidney disease: ,25 Moreover, NOS3 and NOS2—although not associated with CKD in OMIM—have been implicated in CKD in multiple studies,26, 27, 28, 29 whereas MEF2C, a gene typically associated with neurodevelopmental disorders, has also been associated with estimated glomerular filtration rate (eGFR) or proteinuria.30