Specifically, we have predicted the following sets of most likely novel disease-associated genes: AMER1, CCP110, CAT, SERPIND1, GNPTAB, ITPR3, ARHGAP1, CCDC39, FBLN1, HSPA5, and ERBB4 for CKD; IFT57, MED1, and NFASC for epilepsy; and NF2, SZT2, ACADVL, MED12, TSC2, EP400, RYR2, VCL, and BBS2 for ALS. The gene discussed is RYR2; the disease is epilepsy.