All serum concentrations of the inflammation factors (IL-6, IL-18, TNF-α and CRP) detected in this study showed significantly higher in all the PCOS groups compared to the control group (P < 0.01, Fig. 4), and all these factors were significantly decreased in the lower supplementation of glutamine (P < 0.01). The gene discussed is IL6; the disease is polycystic ovary syndrome.