Due to the definition used to characterize the obesity phenotypes, the MUO and MHO groups would differ in cholesterol and TG levels; the lipoprotein profiling showed that this difference is mediated by significant higher or lower concentration of the whole spectrum of VLDL particles, IDL and L-LDL, ApoB, TG and PL, in the MUO and NW groups, compared with the MHO group, respectively. Here, APOB is linked to obesity due to melanocortin 4 receptor deficiency.