Then, we used cBioPortal to analyze 562 differentially overexpressed genes in the PHGDH high group (mRNA Z‐score > 0) compared with the PHGDH low group (mRNA Z‐score ≤ 0) in TCGA BLCA cohort (Fig. 6A) to check whether genes on the serine and glycine biosynthesis pathway were accelerated in concert with PHGDH expression. This evidence concerns the gene PHGDH and bladder transitional cell carcinoma.