EGFR and non-small cell lung carcinoma: Numerous randomized trials have demonstrated the superiority of small-molecule EGFR tyrosine-kinase inhibitors (TKIs) over cytotoxic chemotherapy for the treatment of EGFR-mutant NSCLC patients and, thus, have been established as standard first-line therapy (Mok et al. 2009; Rosell et al. 2012; Sequist et al. 2013).