There were significant differences in the tumor size > 5 cm and the level of serum AFP ≥ 400 ng/ml between MVI-positive and MVI-negative groups (p = 0.006 and p = 0.022, respectively), but when the serum level of AFP was between 20 and 400 ng/ml, there was no significant differences between the two groups. This evidence concerns the gene AFP and neoplasm.