From these, 57 proteins had a decreased abundance including haptoglobin (Q61646), fibulin-5 (Q9WVH9), as well as proteins with reported involvement in cancer like SPARC-like protein 1 (P70663) [61], osteopontin (P10923) [62], and annotated proteases like serine protease HTRA3 (Q9D236), and the protease inhibitor antileukoproteinase (P97430). This evidence concerns the gene SPP1 and cancer.