SCAP and metabolic syndrome: Furthermore, in a recent study regarding the molecular mechanisms of crosstalk between the inflammatory response and dyslipidemia, the loss of SCAP attenuated lipopolysaccharide-stimulated IκB phosphorylation in human macrophages and decreased the level of p65 in the nucleus, suggesting that SCAP dysfunction stimulates the inflammatory response by activating the NF-κB signaling pathway33.