Since Caspase-1 is the main downstream effector of all inflammasomes, Casp1-KO mice may be considered as representative of a global inflammasome loss of function, which in our experimental model was associated with a significant attenuation of inflammatory bone resorption, indicating that Caspase-1 activation in the microenvironment of periodontal disease has a relevant role in the inflammatory bone resorption. This evidence concerns the gene CASP1 and periodontal disorder.