There was no statistically significant difference on the overall inflammatory infiltrate (CD45 + cells) in diseased gingival tissues among the three genotypes; however there was a significant decrease on the PMN (Ly6G + ) infiltrate in Casp1-KO mice, which also had the least relative increase of PMN infiltration with the induction of experimental periodontal disease. This evidence concerns the gene PTPRC and periodontal disorder.