Induction of experimental periodontal disease was associated with a marked increase in inflammatory cell infiltrate in WT, Nlrp3-KO mice and Casp1-KO mice (Fig. 3A, inflamed area corresponding to the site of injections indicated by an asterisk, ‘BC’ indicates the alveolar bone crest and ‘R’ indicates the palatal root of the upper first molar, H/E stained images). The gene discussed is CASP1; the disease is periodontal disorder.