Although there are no reports on the changes in plasma thyroid hormones under hypergravity, a collapse of thermoregulation in the 2g environment might not be the sole factor responsible for sympathoinhibition; hypothyroidism may also be an important factor, because administration of beta-adrenergic receptors agonists did not completely reduce hypothermia (Fig. 2e). The gene discussed is TG; the disease is hypothyroidism.