They further reported associations between several tumour suppressive micro ribonucleic acids (miR-126-3p, miR-154-5p and miR-21-5p), an miR processing ribonuclease (DICER-1), and elevated levels of 1,25(OH)2D. This tumour suppressive miR and DICER-1 are known to be associated with reduced risk of PC recurrence thus suggesting that 1,25(OH)2D may alter the microenvironment to regulate the interaction between stroma and epithelium in prostate tissue in a pathway involving miRs27,28. The gene discussed is DICER1; the disease is pachyonychia congenita.