In brief, both CD16− and CD16 + monocytes of T-NHL patients had increased expression of C1QC, C1QB, CD274(PDL1), GBP5 and TNFRSF12A. HLA-B, HLA-C, HLA-DQA1 were highly expressed in CD16− monocytes in patients while SDC3, KCNMA1, IL31RA, PDCD1LG2(PDL2), CXCL9, ID1, AREG, CD72, PIM1, especially CCL4 were highly expressed in CD16 + monocytes compared to the control. Here, GBP5 is linked to non-Hodgkin lymphoma.