Therefore, this study was undertaken to verify on a larger series of patients whether an association exists between thrombotic events (arterial or venous thrombosis) or recurrent pregnancy loss (RPL) and anti-DFS70 antibodies and whether the high prevalence of anti-DFS70 antibodies in these disease groups described by Marlet using the IIF method could be confirmed by DFS70 specific methods. The gene discussed is PSIP1; the disease is Venous thrombosis.