Finally, since heparin has been shown to be a stabilizing factor of DFS70/LEDGF, protecting it from proteolytic degradation under various stress conditions29, to ascertain a possible role played by heparin treatment in anti-DFS70 expression, we included in this series of patients 25 subjects who had a venous or arterial thrombosis currently under heparin therapy and 45 subjects without thrombosis on prophylactic treatment with heparin before orthopedic surgery. The gene discussed is PSIP1; the disease is Arterial thrombosis.