Because the spatial organization of mTOR is coordinated through a variety of sensors and regulators that converge on Rag GTPases63, the phagosomal regulation of LAMTOR by melanin55 suggests similar mechanisms during fungal infection, in line with the ability of melanized conidia to inhibit phagosomal recruitment of CaM, and prevent the specialized autophagy pathway LC3-associated phagocytosis (LAP)43. The gene discussed is MTOR; the disease is fungal infectious disease.