We treated YFP–α-synuclein overexpressing SH-SY5Y cells with CDDO-Me to inhibit Lon protease (43), which has recently been shown to influence aggregate dissolution after heat shock (44), and with UCF-101 to inhibit high temperature requirement protein A2 (HtrA2/Omi) protease (45), which has previously been linked to PD. The gene discussed is HTRA2; the disease is Parkinson disease.