NLGN3 and Alzheimer disease: Clustered proteins positively associated with preclinical AD were further individually analyzed, revealing a significant boost of the immune response in presymptomatic AD (modulated SSB, PAF, and Thy-1 membrane glycoprotein CD90 proteins) and modulation of the synapse structure (NLGN3) and the angiogenesis-associated protein OGFR (Fig. 3b—I to III).