Neurofibromatosis type 1 (NF1) is characterized by multiple café au lait spots and cutaneous and plexiform neurofibromas (NFomas), and is one of the most common autosomal dominant hereditary disorders caused by mutations of the NF1 tumor suppressor gene (NF1) on chromosome 17 [1–3]. This evidence concerns the gene NF1 and autosomal dominant disease.