Furthermore, it was reported that FGF23 acts on sodium–phosphorus co-transporter in the renal tubule and inhibits 1α-hydroxylation of 25-hydroxyvitamin D3 (25(OH)D3); thus, leading to renal phosphate leakage, hypophosphatemia, inappropriately normal or low 1α25-dihydroxyvitamin D3 (1α25(OH)2D3) levels, and decreased bone mineralization [10]. The gene discussed is FGF23; the disease is hypophosphatemia.