Intravenous infusion of GLP-1 significantly increased CrCl in both Sham + T-RDN (2978 ± 213 vs. 2225 ± 94 μl/min/gkw, P < 0.05, n = 5) and HF + T-RDN group (2868 ± 178 vs. 1725 ± 108 μl/min/gkw, P < 0.05, n = 5). This evidence concerns the gene GCG and hydrops fetalis.