This is in line with a previous study from the CAST cohort, where we found a correlation between pathological cerebrospinal fluid (CSF) concentrations of microtubule-associated protein tau (T-tau) 1 year post-stroke and brain atrophy, indicating that tau-linked neurodegeneration might be more important than amyloid post-stroke [68]. The gene discussed is MAPT; the disease is Brain atrophy.