NIPA2 and Angelman syndrome: Although NIPA1 and NIPA2 share related KEGG and Reactome pathways (Table 3 and Table 6), their cardinal disease associations are different (Table 15): Spastic Paraplegia 6, Autosomal Dominant and Spastic Paraplegia 6 for NIPA1 and Angelman Syndrome and Prader–Willi Syndrome for NIPA2. However, as shown in Table 16, they both are also associated with PWS and AS.