Although NIPA1 and NIPA2 share related KEGG and Reactome pathways (Table 3 and Table 6), their cardinal disease associations are different (Table 15): Spastic Paraplegia 6, Autosomal Dominant and Spastic Paraplegia 6 for NIPA1 and Angelman Syndrome and Prader–Willi Syndrome for NIPA2. However, as shown in Table 16, they both are also associated with PWS and AS. This evidence concerns the gene NIPA1 and Angelman syndrome.