Except for the TUBGCP5 gene, all three remaining genes are associated with Angelman syndrome, although the TUBGCP5 gene is located most proximal to the Angelman syndrome gene, UBE3A. TUBGCP5 gene is also not associated with attention deficit hyperactivity disorder and learning disability, developmental disorder, and peripheral nervous system disease. The gene discussed is UBE3A; the disease is attention deficit-hyperactivity disorder.