NPM1 and acute myeloid leukemia: We can, therefore, identify two types of clinical presentations according to the frequency of leukemic stem cells: a slowly progressive disease with a preserved general condition, low white blood cell count, secondary AML, adverse cytogenetics, and a high frequency of iLSCs, as opposed to a more aggressive disease, poorer performance status, hyperleukocytosis, intermediate cytogenetic risk, NPM1 mutations, and a low frequency of iLSCs.