The comparison of the characteristics of the population of the present study with the population described by Santos et al. shows that although age (65 vs. 68 years old, respectively), gender distribution (59.5% vs. 62% of women) and disease duration (7 vs. 10 years) do not appear very different, the HbA1c values (7.2% vs. 8.1%) and the proportions of individuals taking insulin (25% vs. 67.2%) indicate that, as expected, the population followed in the tertiary center presented a more severe T2D. The gene discussed is INS; the disease is type 2 diabetes mellitus.