Similarly, aggressive glioma cells expressing EGFRvIII, a truncated oncogenic form of the epidermal growth factor receptor (EGFR), released EVs containing EGFRvIII which were taken up by recipient glioma cells lacking this isoform, thus promoting the activation of the MAPK and Akt signaling pathways [94]. This evidence concerns the gene AKT1 and central nervous system cancer.