The AD + EYP combination group demonstrated significantly decreased expression of Bax (p = 0.038), cytochrome c (p < 0.001), apaf-1 (p = 0.033), and cleaved caspase-3 and -9 (p = 0.041, p = 0.023, respectively), and significantly increased expression of Bcl-2 (p = 0.039) compared with the AD group. The gene discussed is APAF1; the disease is Alzheimer disease.