There were significant differences in apoptosis between AD + YP and AD + EYP groups (Bax: p = 0.034, Bcl-2: p = 0.015, cytochrome c: p = 0.028, apaf-1: p = 0.039), cleaved caspase-3: p = 0.029 and -9: p = 0.020). This evidence concerns the gene APAF1 and Alzheimer disease.