Moreover, TCGA (The Cancer Genome Atlas) data revealed that the expression of p62 was significantly lower in primary tumors, such as colorectal cancer, breast cancer, prostate adenocarcinoma/prostate cancer, and bladder cancer/bladder urothelial carcinoma, than those of normal primary cells (Supplementary Materials Figure S5A–D). This evidence concerns the gene SQSTM1 and colorectal cancer.