Interestingly, p62-deficient cancer cells, p62-knockdown (p62KD) SK-HEP-1, p62KD MDA-MB-231, and p62-knockout (p62KO) A549 cells, exhibited increases in autophagic activation, and cancer cell migration/invasion induced by TLR4 stimulation. The gene discussed is SQSTM1; the disease is cancer.