Since p62 negatively regulates TLR4-mediated signals through the inhibition of TRAF6-ECSIT signaling [13], we therefore investigated whether p62 is functionally implicated in the TRAF6-BECN1 signaling axis, thereby regulating autophagy activation, and cancer cell migration and invasion induced by TLR4. The gene discussed is SQSTM1; the disease is cancer.