As for DTX3L, ATRA causes detectable increases of the protein levels in two luminal (SK-BR-3, CAMA1) and three basal (HCC-1599, MB-157, MDA-MB-157) cell-lines endowed with high and intermediate retinoid-sensitivity, which is largely consistent with what is observed at the mRNA level (Figure 7B). This evidence concerns the gene DTX3L and hepatocellular carcinoma.