Later on, the enhanced expression of the SASP factors CXCL12, HGF, MMPs and TGFβ in irradiated fibroblasts was reported to increase EMT and invasiveness of cancer cells, and enhanced expression of the SASP factors EGF, FGF-4, GM-CSF, IGF-1,2, IGFBP-2,4,6 induced chemoradioresistance in cancer cells [90]. This evidence concerns the gene CXCL12 and cancer.