IL4 and systemic lupus erythematosus: On the other hand, IL-6 establishes a bridge between the activation of T- and B-lymphocytes; IL-6 promotes the survival, activation, expansion, and maturation of B-lymphocytes and plasma cells, promoting the development of follicular T-lymphocytes [33], these cells located in the follicles of B-cells within the lymph nodes, promote the proliferation and class switching of B-lymphocytes through cytokines such as IL-4 [34], as previously described in autoimmune diseases such as SLE [35].