IL18 and interstitial lung disease: According to the results of this study, the baseline cytokines levels are consistent with a highly heterogeneous inflammatory response; however, at follow-up, only the patients with ILD progression showed higher levels of cytokines such as IL-1β, IL-4, IL-6, IL-10, IL-17A, IL-18, IL-22, GM-CSF, and TNF-α; these findings allow us to frame the immune response, such as the Th17 profile, and propose a pathophysiological pathway (Figure 4).