IL6 and autoimmune disease: A finding worth noting is that elevated tumor necrosis factor α(TNF-α) and IL-6 levels in SAHS patients have been observed and correlated with daytime sleepiness and disease severity.[15] Meanwhile, RA, AS, and inflammatory bowel disease are reported associated with dysregulation of TNF-α signaling.[16] Second, SAHS and autoimmune disease may share some genetic background and risk factors.