The optimal combination was the association of increased levels of KL-6 (>632 U/mL), SPD (>19 ng/mL) and CCL18 (>83 ng/mL), which increased sensitivity from 68% to 77%, specificity from 83% to 97%, PPV from 60% to 69% and NPV from 87% to 97% (Table 2). The gene discussed is CCL18; the disease is Platelet storage pool disease.