ALS2 and juvenile amyotrophic lateral sclerosis: For example, mutations in the ARHSP gene ERLIN2 (SPG18) have been reported in JALS patients and mutations in the JALS gene Alsin (ALS2) have been reported as the cause of ARHSP (Al‐Saif, Bohlega, & Al‐Mohanna, 2012; Eymard‐Pierre et al., 2002; Hadano et al., 2001; Wakil et al., 2014; Yang et al., 2001; Yildirim et al., 2011).