By contrast, transwell experiments showed that cell migration and invasion abilities were restrained after transfecting PAK5△CRIB or PAK5△IBD, but not in cells treated with wild‐type PAK5 or PAK5 (K478M) (Figure 5H), demonstrating that Cdc42 and Integrin β1, β3 are involved in PAK5‐accelerated CRC cells migration and invasion. Here, CDC42 is linked to colorectal carcinoma.