PAK5 and colorectal carcinoma: By contrast, transwell experiments showed that cell migration and invasion abilities were restrained after transfecting PAK5△CRIB or PAK5△IBD, but not in cells treated with wild‐type PAK5 or PAK5 (K478M) (Figure 5H), demonstrating that Cdc42 and Integrin β1, β3 are involved in PAK5‐accelerated CRC cells migration and invasion.