The metastatic nodules on the liver were also monitored and recorded, showing diminished metastatic tumor nodules number in pLKO.1_shPAK5 group vs pLKO.1_Ctrl group (Figure 6C), demonstrating that PAK5 accelerated the proliferation and metastasis of CRC cells in vivo. The gene discussed is PAK5; the disease is colorectal carcinoma.