Moreover, annexin V/7‐AAD staining assay showed that ectopic expression of PAK5 enabled SW480 and HT‐29 cells to be resistant to 5‐fluorouracil (5‐FU)‐induced apoptosis (Figure 2G,H), indicating that PAK5 potentiated CRC cells proliferation and survival capability. This evidence concerns the gene PAK5 and colorectal carcinoma.