IFITM5 and osteogenesis imperfecta: The missense IFITM5 variants (p.Ser40Leu; p.Ser40Trp) cause a more severe OI phenotype that is similar to OI6, but not OI5, such as blue sclera and dentinogenesis imperfect (Fitzgerald et al., 2013; Grover et al., 2013; Rauch et al., 2013).