ATM and breast carcinoma: We found several missense variants in the (suspected) moderate‐risk genes ATM, CHEK2 and RAD51C. The effect of missense changes in ATM and CHEK2 on breast cancer risk is, besides a few specific examples, largely uncertain.33, 34, 35 None of the variants listed in Table 3 belong to any of these exceptions, but some do have CADD scores >20 suggestive of pathogenicity.