With regard to the common low‐risk variants, our results are consistent with studies which have found that non‐BRCA1/2 familial breast cancer cases have a higher PRS than both cases from the general population and cases who carry a BRCA1 or BRCA2 pathogenic variant.47, 48, 49, 50 Whether the prevalence of rare missense variants in the known breast cancer genes we observed in our families is causally linked to breast cancer, will need very large case‐control studies to substantiate further. This evidence concerns the gene BRCA2 and breast carcinoma.