NFKB1 and rheumatoid arthritis: Membrane bound (m)TNFα is elevated on the surface of blood neutrophils in RA patients with active disease, and NF-κB activation levels (which may be triggered via TNFα signalling) are elevated, but both surface mTNFα levels and NF-κB activation levels return to healthy control levels during successful TNFi therapy (Wright et al. 2010).