Indeed, sequential distribution patterns have been recognized for tau pathologies such as neurofibrillary degeneration in Alzheimer’s disease (AD) [3], Pick’s disease [15], argyrophilic grain disease [35], or astrocytic tau pathologies [24] as well as for other proteinopathies such as beta-amyloid, alpha-synuclein or TDP-43 (for review see: [19]). Here, MAPT is linked to proteostasis deficiencies.