Importantly, neuronal tau pathology was observed in the locus coeruleus and hippocampus also; however, at least for PSP-RS, we showed that this was independent from the involvement of strategic subcortical and brainstem nuclei, and might represent or overlap with other pathogenic events such as AD or PART or, particularly for the hippocampus and amygdala, with the presence of AGD, which was frequently seen in our cohort (40.2%). The gene discussed is MAPT; the disease is argyrophilic grain disease.